Table of Contents

2016 Month : December Volume : 2 Issue : 2 Page : 29-30

EMERGING DRUG TARGETS FOR TUBERCULOSIS.

T. Rajathilagam1,

Corresponding Author:
Dr. T. Rajathilagam,
#8/19, Kambar Street,
Metha Nagar,
Chennai-29.
E-mail: rajathilagamtr@yahoo.co.in

ABSTRACT

BACKGROUND

The goal of Tuberculosis (TB) drug discovery and development is to achieve TB drugs and drug regimens that are well understood and superior to those available today in their efficacy, speed of action, safety and tolerability, ease of use for all patient populations and accessibility. Strategies recently used in TB drug development include re-evaluation of existing TB drugs to optimise their utility; repurposing of drugs registered for non-TB indications as components of TB drug combinations; development of improved analogs of compounds or drugs with some known but limited value for TB and development of novel chemical entities with new modes of action against TB. The emerging drug targets for TB are targeting Mtb Iron Acquisition and Storage, MmpL, Cholesterol Metabolism, Targeting Energy Generation: Inhibitors of the Respiratory Chain and ATP Synthesis and cytochromes. Such vulnerable pathways and processes might provide a path toward safer, novel regimens for TB with greater treatment-shortening potential.

KEYWORDS

Tuberculosis, Drug Targets, Drug Regimens, Novel Mechanism.

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