Table of Contents

2017 Month : June Volume : 3 Issue : 1 Page : 1-4

COMPARATIVE EFFICACY AND SAFETY OF IPRATROPIUM BROMIDE VERSUS TIOTROPIUM BROMIDE FOR MAINTENANCE THERAPY OF MILD-TO-MODERATE BRONCHIAL ASTHMA IN ADULTS.

Momin Mohd. Abdul Mujeeb1, Syed Mohsin Ahmed2, Tushar Balchand Chudiwal3

Corresponding Author:
Momin Mohd. Abdul Mujeeb,
Flat No. 203, A-Building,
Premdeep Apartment,
Udyam Nagar, Near Master Bakery,
Pimpri, Pune-411018,
Maharashtra.
E-mail: mominmujeeb29@rediffmail.com

ABSTRACT

BACKGROUND

Anticholinergic drugs are commonly used for maintenance therapy of bronchial asthma. Selective beta-2 agonist like Salbutamol is associated with undesirable side effects like tachycardia and hypokalaemia. The objective of this study is to compare the efficacy and safety of Ipratropium bromide versus Tiotropium bromide for maintenance therapy of bronchial asthma.

MATERIALS AND METHODS

A randomised double-blind clinical study was conducted including 100 known asthma patients. After adequately treating the acute attack, these study medicines were given Ipratropium bromide 2 - 4 puffs 6 hourly or Tiotropium bromide 1 rotacap once a day. The patients were analysed by improvement in clinical symptoms, breathlessness and forced expiratory volume in 1 second. Spirometry was performed three times and the best of the three values were recorded. The following parameters were recorded: Asthma score, Heart Rate (HR), Respiratory Rate (RR), Oxygen Saturation (SPO2), FEV1 (Forced Expiratory Volume in 1 second) and Serum potassium level was determined.

RESULTS

In Ipratropium group, there was significant increment in FEV1 and SPO2 (p < 0.05) with decreased tachypnoea and asthma score, while no significant difference was found in pre- and post-treatment HR and serum K+ levels. In the Ipratropium bromide group although there was clinical improvement in terms of FEV1, SPO2 and asthma score, it resulted in significant tachycardia and decrease in K+ levels. This study showed both Tiotropium and Ipratropium are effective bronchodilators in mild-to-moderate asthma patients.

CONCLUSION

Tiotropium bromide is equally effective as compared to Ipratropium bromide in terms of asthma parameters for maintenance therapy of mild-to-moderate asthma, but in terms of dosage schedule it is convenient to patient.

KEYWORDS

Ipratropium Bromide, Tiotropium Bromide, Mild-to-Moderate Asthma.

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