Table of Contents

2017 Month : June Volume : 3 Issue : 1 Page : 10-14

COMPARATIVE STUDY OF RECOVERY RATE OF TOPICAL CLOTRIMAZOLE AND POVIDONE-IODINE FOR CONTROLLING SUPERFICIAL FUNGAL SKIN INFECTION.

Momin Mohd. Abdul Mujeeb1, Tushar Balchand Chudiwal2, Arvind Punja Salve3, Syed Mohsin Ahmed4

Corresponding Author:
Momin Mohd. Abdul Mujeeb,
Flat No. 203, A-Building,
Premdeep Apartment,
Udyam Nagar, Near Master Bakery,
Pimpri, Pune-411018,
Maharashtra.
E-mail: mominmujeeb29@rediffmail.com

ABSTRACT

BACKGROUND

Topical agents are used to treat wound infections. Superficial skin fungal infections can be associated with many complications including involvement of the deeper layers and systemic manifestations in rare cases. Management of superficial skin infections can be challenging, and requires a close follow-up. Treatment options for this include local debridement, local and systemic antifungal agents and utilisation of topical antiseptics.

Aims and Objectives- The present work was aimed to find out the in vitro efficacy of different topical agents for wound pathogens. This study was designed to compare the recovery rate of superficial skin infections using two therapeutic methods; topical Betadine (Povidone-iodine) and clotrimazole.

 

MATERIALS AND METHODS

In this single-blind clinical trial, 300 patients with mycosis were selected using a non-probability convenient sampling method and were randomly assigned to two treatment groups of topical Povidone-iodine and clotrimazole (150 patients in each group). Response to treatment was assessed at 4, 10 and 20 days after treatment. Data were analysed using the independent t-test, Chi-Square and Fisher exact test in SPSS V18 software, at a significance level of p < 0.05.

Study Design- Randomly selected Gram-positive and Gram-negative bacterial isolates from infected wound cases admitted & outdoor were included in the in vitro activity testing.

RESULTS

The results showed that out of 300 patients with superficial skin mycosis, fungi type isolated included Aspergillus in 222 cases (74%), and Candida albicans in 159 patients (26%). On the fourth day after treatment, 39 patients (13.1%) in the group treated with Betadine and 27 patients (9.8%) in the group treated with clotrimazole showed a good clinical response to treatment (p = 0.75). A good response to treatment was reported for 130 (87%) and 69 patients (46.1%) on the tenth day after the treatment (p = 0.02); and 138 (92%) and 100 patients (67%) on the twentieth day after treatment (p = 0.01) in the groups treated with clotrimazole and povidone-iodine, respectively. The response to treatment was found to be more significant for clotrimazole.

CONCLUSION

In the present study, the efficacy of Povidone-iodine and clotrimazole was assessed for its efficacy and safety. The result of this study supports the use of clotrimazole, more effective antifungal in superficial skin fungal infection treatment, helping to avoid the emergence of resistant organisms.

KEYWORDS

Povidone-iodine, Clotrimazole, Recovery Rate.

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